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Irinotecan, Carboplatin, and Imatinib in Untreated Extensive-Stage Small-Cell Lung Cancer: A Phase II Trial of the Minnie Pearl Cancer Research Network

Christen, Stephan
First-pass metabolism destroys 85-87% of the oral dose. Nitroglycerin: So much is destroyed by first-pass metabolism that its deliberately given under the tongue (sublingual) or through skin patches to bypass hepatic metabolism entirely

The mRNA amount of IL6 and VEGF was reduced in the ischemic hindlimb of wild-type mice (90)
