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This allowed us to determine whether curcumin induces phosphorylation changes converging on cytoskeletal regulation, similar to those triggered by microtubule stabilization

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Zinc also regulates the endolysosomal tethering machinery through the HOPS complex, whose VPS18 and VPS41 subunits contain zinc-binding RING domains essential for heterodimer formation and complex stability, which is critical for autophagosomelysosome and endosomelysosome fusion 104