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Notably, the extracellular concentration of adenosine triphosphate (ATP) increases substantially following TBI due to cell damage and lysis

The increase in leu-enkephalin levels adds another anxiolytic dimension

Rodilla, V

I highlight particularly how synergies with other DAMPs can render immunogenic properties to normally non-immunogenic extracellular self-DNA, and I discuss the shared features of the gp41 unit of the HIV-1 envelope protein and the SARS-CoV 2 Spike protein that enable HIV-1 and SARS-CoV-2 to interact with cell or nuclear membranes, trigger syncytia formation, inflict damage to their hosts DNA, and trigger inflammation likely for their own benefit