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These findings suggest that LILRB1+ ICs act as independent prognostic indicators and may predict weaker responses to immunotherapy, positioning LILRB1 as a promising target for future therapeutic approaches in OC treatment (142) MUC2 MUC2 is a mucin glycoprotein that is aberrantly overexpressed in ovarian cancer, contributing to tumor progression by influencing immune cell behavior, particularly macrophages (143)

According to several authors, stromal macrophages play a key role in the development of para-inflammation (low-grade inflammation), as they increase their pro-inflammatory activity and enter networked interactions with other resident cells and with leukocytes that migratealbeit moderatelyinto the para-inflammatory zone [867,868,869,870,871]

S., Helmby, H

Ethics declarations Competing interests A