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doi: 10.1038/ncb1724 162 MathupalaSPHeeseCPedersenPL

Genes 13:1231

5,6 TABLE 1 Clinical Manifestations of Vitamin B12 Deficiency In addition to hematologic and neuropsychiatric manifestations, vitamin B 12 deficiency may exert indirect cardiovascular effects

The magnitude of Chac1 downregulation exceeded that of canonical refeeding-responsive genes controlling hepatic glucose metabolism, such as the downregulation of G6pc or upregulation of Gck (Figure 6A), indicating robust transcriptional suppression of Chac1 during feeding
