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Shou et al showed that repeated electroacupuncture at specific acupoints improved thermal hyperalgesia and increased D1 and D2 gene expression levels.47 Zhang et al found that in morphine-dependent rats, both the latency of pain-excitation neurons discharges and the inhibitory duration of pain-inhibition neurons discharges were altered.48 DA inhibited pain-excitation neurons and augmented pain-inhibition neurons, indicating that DA plays a role in modulating pain signal transmission in morphine-dependent rats
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