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Mechanistic differences: Matrixyl acts as a matrikine -- a peptide fragment derived from extracellular matrix proteins that signals cells to increase collagen synthesis

16 Of note, in the completed Phase 3 study and in the ongoing long-term follow-up trial (NCT03373968), participants receive glucocorticoid therapy concurrently with Givinostat

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found that the abnormal accumulation of double-stranded DNA in the cytoplasm may bind to the cytoplasmic DNA sensor (cGAS), thereby specifically triggering the STING-interferon (IFN) signaling pathway in microglia, promoting the expression and secretion of inflammatory cytokines