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Results revealed that muscle stem cell proliferation and fusion were substantially elevated in treated aged mice, supporting nearly twofold greater myofiber cross-sectional area and shifts in fiber size distribution toward larger, healthier muscle fibers

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Primary MM plasma cells were isolated from BM aspirates by immunomagnetic separation using anti-CD138 monoclonal antibody-coated microbeads (Miltenyi Biotec, Bergisch Gladbach, Germany) ( 2.2 Cells and microvesicle phenotypes Surface molecule expression on LP-1 and BF01 MM cell lines, primary human BM mononuclear cells, and primary MM cells was analyzed as previously described (45, 57)