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However, research indicates that our natural levels of GHK-Cu decrease as we get older, dropping significantly by the time we hit age 60

doi: 10.2106/00004623-200207000-00005
Variability in how individuals handle drugsdue to genetics, disease states like renal or hepatic insufficiency, age, or drug interactionscan lead to significant differences in plasma concentrations from a given dose, resulting in either therapeutic failure or adverse events

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