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There are two major kinds of non-viral delivery systems for the intracellular delivery of nucleic acid based antiviral drugs (like DNA vaccines, antisense oligonucleotides, ribozymes, catalytic DNA (DNAzymes) or RNA molecules, siRNAs or plasmids encoding thereof), comprising lipoplex systems (cationic liposomes containing DNA) and polyplex systems (DNA attached to a cationic polymer)

doi: 10.3390/diagnostics10080601 195 StevensTWMatheeuwsenMLnnkvistMHParkerCEWildenbergMEGecseKBet al

For this reason, experts advocate using only supervised clinical settings with greater regulation as a means of protecting patients

However, some peptides are more stable at slightly acidic pH values