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Disorders where NAC or other nicotinamide-based treatments are commonly used as adjunctive therapies are often conditions in which sleep is taxed and tissue-level oxidative stress is high

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The pathogenesis of ALD involves multiple interconnected aging-related processes, including oxidative stress, inflammation, and mitochondrial dysfunction, all of which are regulated by SIRT1, a key modulator of cellular stress responses (Ramirez et al., 2017)

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