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Intestinal tight junctions (TJ) are responsible for the paracellular trafficking of macromolecules and, therefore, they contribute to the balance between tolerance and immune response to non-self antigens (1)

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Hrd1 can recognize and bind NRF2, directing it to the ERAD pathway for ubiquitination and proteasomal degradation [55]

Additionally, signal transducer and activator of transcription 3 (STAT3) activation (phosphorylation at Tyr705) in GBM cells promotes immune evasion associated with reduced numbers of phagocytes, decreased phagocytosis, and inhibition of T cell proliferation (38)