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The honest answer, based on the available research, is that the effect is real and directionally consistent with the physiology, but modest under ordinary circumstances not the dramatic swing implied by many unsourced blog claims

Most recently, our approach to pK a prediction, which uses only internuclear distances as descriptors, called AIBL-pK a (ab initio bond lengths), showed remarkably accurate prediction of acidity variation across congeneric series of guanidine-containing species 19 and sulfonamides 20

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Nevertheless, as the usage of BPC-157 for healing purposes remains experimental