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Any perturbation of this balance, caused by excessive production of disulphide bonds during normal protein secretion or the production of mutant misfolded protein, might cause an excess of ROS to accumulate and ultimately lead to cell death

Tirzepatide, in contrast, may address the root cause: metabolic dysfunction

10.1517/13543784.14.8.1047 122 ThomR.CumminsI.DixonD
