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Nutrition experts have not established a tolerable upper intake level for vitamin B12 (the maximum safe amount per day)

Eur J Pharmacol 134(2):245248 Stuerenburg HJ, Petersen K, Bumer T, Rosenkranz M, Buhmann C, Thomasius R (2002) Plasma concentrations of 5-HT, 5-HIAA, norepinephrine, epinephrine and dopamine in ecstasy users

They have been shown to have an anti-inflammatory effect - both mechanical as well as biochemical in inhibiting phagocytosis, reducing levels of prostaglandins, interleukin 1, free radicals and cyclic AMP

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