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The substantial weight reduction observed with tirzepatide monotherapy (15-21% body weight in clinical trials) suggests that any perceived benefits likely reflect tirzepatide's pharmacological effects rather than synergistic action

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Meanwhile, we verified the results using another three MR methods, namely Mendelian randomization Egger regression, weighted median and weighted mode

Your doctor will be able to tell you more about its safety in your circumstances and will also be able to recommend other measures to help you achieve your aims