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staggered titration Cycle driver GI tolerance sets the pace Retatrutide Loading 2 mg 4 mg 8 mg (weeks 1-12) Frequency Once weekly Maintenance 12 mg weekly Route SubQ Cagrilintide Loading Start Week 9: 0.25 0.5 1.0 1.7 mg Frequency Once weekly Maintenance 2.4 mg weekly Route SubQ Weekly Schedule Example (Maintenance Phase) Monday Retatrutide 12 mg (one site) + Cagrilintide 2.4 mg (different site) Tuesday No injections Wednesday No injections Thursday No injections Friday No injections Saturday No injections Sunday No injections Both compounds are once-weekly

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2 for varying sets of parameters and to dissect the contribution of the individual kinetic process to the downstream signal and desensitization

In the phase III Hovon-65/HMMG-HD4 trial, BDD was compared to vincristine Adriamycin and dexamethasone (VAD) induction followed by autologous stem cell transplant (ASCT) followed by thalidomide maintenance in the VAD group and bortezomib maintenance in the BDD group [30]
