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The time it takes for vitamin B12 (cobalamin) treatment to produce noticeable effects varies considerably depending on the severity of deficiency, the route of administration, and individual patient factors

The 4 stages of B12 deficiency include (31): Stage 1: decreased levels of vitamin B12 in your blood Stage 2: low levels of vitamin B12 in your cells along with metabolic abnormalities Stage 3: neurological and psychological symptoms like anxiety, confusion, problems with balance, and others Stage 4: macrocytic anemia very large red blood cells (32) B12 deficiency can cause a variety of symptoms, including fatigue, headaches, depression, pale or yellow skin, mental impairment, and pain and inflammation in the mouth and tongue

However, individuals should consult with their healthcare provider if they experience any unusual or persistent symptoms after receiving B12 injections

Follow-up sessions or periodic maintenance benefit most patients based on the chosen treatment