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Cortisone had a job to do, and for a while, it did it

Meanwhile, M2 macrophages-derived extracellular vesicle (EVs) could also convert activated M1 macrophages into M2 macrophages through in situ macrophage reprogramming and producing a distinct protein expression pattern characteristic of anti-inflammatory M2 macrophages

(3) the synthesis of significant amounts of reduced nicotinamide adenine dinucleotide phosphate (NADPH) via the pentose phosphate pathway, which acts as a reducing agent against oxidative stress and generates ribose 5-phosphate for purine nucleotide biosynthesis