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Henke N, Albrecht P, Bouchachia I, Ryazantseva M, Knoll K, Lewerenz J, Kaznacheyeva E, Maher P, Methner A

Ascorbic acid is required to reduce Fe3+ to Fe2+, forming semidehydroascorbic acid in the process

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Further research reveals that rhein can alleviate endoplasmic reticulum stress induced by H/R, upregulate GPX4 and SLC7A11 to mitigate lipid peroxidation, reduce renal ferroptosis, and protect against AKI (185)