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The questionnaire used to assess pain is based on analogical measurement of pain intensity on a scale with 11 points, going from 0 to 10 (PI-NRS), where 0= no pain and 10= worst possible pain
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44,45 Estrogen appears to modulate pain perception in multiple ways, including through effects on nerve pathways and neurotransmitter function, influencing serotonin, dopamine, epinephrine, and endogenous opioid signaling
This study indicated that LC supplementation improves PCOS by decreasing blood glucose levels and opposing insulin resistance [12], which could perhaps be attributed to LC-induced increase in beta-oxidation of fatty acids and basal metabolic rates [39]
