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In those with an insidious course, depending on the nature and amount of damage to the kidney, symptoms such as high blood pressure, chronic fatigue, weakness, night-time urination, foul breath, increased need to drink water, and edema of the legs may occur

Moreover, inflammatory mediators, such as Nucleotide-binding oligomerization domain-like receptor protein 3 (NLRP3) and Tumor necrosis factor-alpha (TNF-) increased, while pivotal proteins involved in dendritic and synaptic development, such as Synaptophysin (SYP), postsynaptic density protein 95 (PSD95) and brain-derived neurotrophic factor (BDNF) decreased in APP/PS1 mice

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