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Specifically, NPY and Y1 receptor knock-out mice showed decreased eosinophils in the bronchoalveolar lavage fluid, as well as decreased circulating immunoglobulin E (IgE) levels, compared to wild-type mice under allergic conditions [178]

Jandric I, Vrcic H, Jandric Balen M, et al

At the very least, immunogenicity would trigger the production of antibodies that neutralize the peptides effects

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