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NAD+ is a critical coenzyme involved in hundreds of enzymatic reactions including glycolysis, the citric acid cycle, and oxidative phosphorylation, as well as serving as a substrate for NAD+-consuming enzymes including sirtuins, PARPs, and CD38

The body appears to develop some tolerance to the GI effects with consistent exposure

The compound's effects extend to muscle tissue, where NNMT inhibition modulates cellular energetics and contractile function