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For the Box Maze, main trial-number effects were analyzed using the Bonferroni posthoc multiple comparisons test to quantify the extent of latency differences

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however, these drugs have been misused Currently available data do not suggest that rhGH treatment should be used to promote longevity Lack of GH action in mouse models is associated with extended longevity, but the mechanism underlying the increased lifespan has yet to be established Given the effects of reduced GH/IGF-1 signalling on lifespan in rodents, decreased GH action might be beneficial for humans, but clinical trials are needed to assess long-term outcome of GH/IGF-1 inhibition This is a preview of subscription content, access via your institution Access options Subscribe to this journal Receive 12 print issues and online access $189.00 per year only $15.75 per issue Buy this article Purchase on SpringerLink Instant access to the full article PDF

The protective variant at rs2304256 was shown to decrease STAT1 phosphorylation in B lymphoblastoid cell lines when stimulated with IFN (67)