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10.1186/s40169-017-0154-5 Clin Transl Med

3 Interactions of gut microbiota with epithelia and gut function The gut epithelium serves important functions, such as nutrient absorption, water and salt homeostasis, surveillance of luminal content as well as protection of the body by building a physicochemical barrier and collaborating with the immune system (Kim and Ho, 2010

Moreover, thiol reducing molecules like glutathione and specific isoforms of thiols reductases, thioredoxins and glutaredoxins were found in different nuclear subcompartments, further supporting that thiol-dependent systems are active in the nucleus

These findings suggest that targeting aged cells may be effective for the treatment of fibrotic lung disease