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Current evidence has documented indices of mitochondrial dysfunction in LC, including dysregulated mitochondrial metabolism, a loss of mitochondrial membrane potential, an altered fatty acid metabolism with dysregulated mitochondrial lipid catabolism, and redox imbalance [149,150]

[37] A 2024 evidence map of 57 randomized controlled trials of complementary and alternative therapies for genitourinary syndrome of menopause identified 31 trials of 20 different phytoestrogen products, 7 trials of vitamin D or E, and smaller numbers of trials of probiotics, acupuncture, yoga, and cognitive behavioral therapy

The protocol balances effectiveness against tolerability