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These highly reactive molecules can cause oxidative damage to cellular components, including lipids, proteins, and DNA, further exacerbating mitochondrial damage and contributing to the development of both CVDs and cognitive impairment

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The effects of SIRT1 on obesity and energy metabolism are, at least in parts, mediated by deacetylation and activation of peroxisome proliferato ractivated receptor coactivator, PGC1 [10, 11, 19] (Fig
