glutathione complex with arsenic trioxide trioxide-based nanoparticles for enhanced chemotherapy by activating pyroptosis Toxicity of Glutathione-Binding Metals: A
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Metastases are than produced with both angiogenic and non-angiogenic areas

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Excessive ROS serve not only as a direct agent causing damage to biological macromolecules but also as a potent second messenger that activates key pro-inflammatory signaling pathways, such as NF-B and MAPK, through the oxidative modification of essential signaling proteins (62)
