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Total synthesis of ISA has been fulfilled (Tada et al., 1993) and so many derivatives provide a chance to easy analyze the structure-activity relationship, which may further facilitate the structural optimization (to enhance the activity and to lower the toxicity) and development of ISA in drug discovery

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[DOI] [PubMed] [Google Scholar] 89.Deng L, Blanco FJ, Stevens H, Lu R, Caudrillier A, McBride M, McClure JD, Grant J, Thomas M, Frid M, et al

This is important since the hydroxyl radical is believed to be the most dangerous oxygen species since there are no naturally occurring mechanisms to prevent its affects