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As IRE1 is the most evolutionarily conserved UPR sensor, we investigated whether it also determines ferroptosis sensitivity in lower organisms

Moreover, the protein and mRNA expressions of iron-responsive element-binding protein 2 (IREB2) were reduced, and hepatocyte swelling was lightened, and the number of fat vacuoles was completely lessened (91)

This primary immunodeficiency classically presents in late childhood or adolescence with recurrent, invasive infections caused by encapsulated Neisseria species, such as recurrent meningococcal meningitis or disseminated gonococcal infection

[DOI] [PMC free article] [PubMed] [Google Scholar] 16.Sekhar R.V., Patel S.G., Guthikonda A.P., Reid M., Balasubramanyam A., Taffet G.E., Jahoor F