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Quercetin was administered at different doses for different periods of time to examine the reversal of hypermethylation in the RASSF1A gene

Cappellini MD, Fiorelli G (2008) Glucose-6-phosphate dehydrogenase deficiency

However, this effect is typically less robust than reduction of drug self-administration and is observed with higher doses of agonist than the minimal effective dose required to reduce drug self-administration (Peters and Kalivas, 2006
