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[DOI] [PubMed] [Google Scholar] 5.Brooker RJ

Excessive ROS production leads to cellular damage, lipid peroxidation, and inflammation, which may contribute to the development and progression of CVDs (88)

The subpopulations of these cells are of particular interest in the topic of malignancies, even though their role usually involves parasitic, helminthic, and fungal infections [35]

Importantly, based on the information presented, it is the authors understanding that multiple pathways of NO consumption likely exist simultaneously thus contributing to poorer prognosis in diseases such as cardiovascular disease, in which bioavailable NO is reduced both by the production of MPO and accumulation of free radicals