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reported no adverse events in a study evaluating a rather interesting dosing regimen, once a week IV NAC infusion (50 mg/kg) supplemented with oral NAC (500 mg BID) on non-infusion days [44]
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doi: 10.1111/j.1523-1755.2004.00860.x
However, prolonged or severe stress can lead to the sustained activation of the ISR and the initiation of processes leading to cell death, due in part to downstream effectors such as ATF4 and its targets, such as DDIT3 (CHOP) (Pakos-Zebrucka et al., 2016)
