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Meanwhile, the RMSD results for the protein reflected minor fluctuations (0.80 1.60) during the 100ns trajectory
During hyperphosphorylation, tau protein dissociates from the microtubule, resulting in the spread of unbound microtubules and progressive accumulation of phosphorylated tau protein followed by the formation of NFTs [96]
Performed the analysis: Farhad Nikzad, Shahin Sabbaghi and Sara Saeedpour
We direct the reader to these useful articles on translation of dose for topical ophthalmic,27 topical dermatologic,28 and inhalation 29 routes of administration
