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Twinlab Twinlab () 1968

PKC phosphorylates CARMA1 [caspase recruitment domain family (CARD)containing membraneassociated guanylate kinase (MAGUK) protein 1] on S668 to lead to the formation and recruitment of the CARMA1, Bcell leukaemia/lymphoma 10 (Bcl10), and mucosaassociated lymphoid tissue 1 (MALT1) complex to lipid rafts to form part of the BCR signalosome.65 PKC is also required in recruiting inhibitor of B (I B) kinase (IKK) to the CARMA1Bcl10MALT1 complex.56 For IKK activation to occur, the adaptor protein CARMA1 is directly phosphorylated by PKC , which then brings IKK and another protein kinase transforminggrowth factoractivated kinase 1 (TAK1) close together.66, 67 This allows TAK1 to phosphorylate IKK leading to its activation.66 As a result, I B is phosphorylated by IKK to lead to activation of NF B, hence demonstrating the critical role that PKC plays in BCRdependent NF B signalling