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21875085, 21373101 and 91027027) and the Opening Program of the State Key Laboratory of Supramolecular Structure and Materials, Jilin University

As suggested above and in figure 1, the methionine cycle and the transsulfuration pathway influence homocysteine concentration and for this reason they are important research targets: The formation of methionine from homocysteine is essential to reduce the risk of homocysteine toxicity, conserve methionine as a substrate for protein synthesis, and produce a principle methylating agent in the form of SAM

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All scale bars are 20 micrometers
