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Cardiovascular Disorders: Patients with these conditions need to be cautious, as excessive thyroxine doses might induce cardiac pain, arrhythmias or heart attacks

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Oxidative Medicine and Cellular Longevity 2013: 956792

This is observed for tyrosine kinase-dependent BDNF-induced excitation via NaV1.9 sodium channels [107] and calcium transients in dendritic spines via voltage-gated calcium channels, leading to LTP induction [108]