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Description
There are numerous reasons for an altered microglial secretory profile in aging, but one specific to white matter regions could be an increase in myelin debris that cannot be efficiently cleared/metabolized by microglia, resulting in cellular stress (Safaiyan et al., 2016)
High bioavailability curcumin formulations are being developed to increase therapeutic concentrations [31]
Meijers SM, Lieftink AF, Stegeman I, Smit AL
Die Dosierungs-Frequenz von ein- bis zweimal tglich ist pharmakologisch begrndet kurze Plasma-Halbwertszeit, lange Gewebe-Wirkung, additive Effekte durch wiederholte Stimulation der Regenerationssignale
