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Description

Beyond GPX4s protection against lipid peroxide-mediated death in conditions like lupus nephritis, the transcription factor NRF2 bolsters cellular redox defenses, while in heart failure, renal proximal tubules sustain high ATP demand through a finely-regulated iron cycleinvolving transferrin endocytosis, DMT1 transport, mitochondrial use, ferritin storage, and ferroportin exportto conserve iron and prevent its urinary loss (119)

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As MTPA-Cl can react with both amine and hydroxyl groups, the reaction between MTPA-Cl and the two modified amino acids generates bis-derivatized products, (MTPA) 2 -K l-la and (MTPA) 2 -K d-la , respectively