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Treatment is typically initiated at very low nocturnal doses (e.g., 1025 mg of amitriptyline) to capitalize on their sedative side effects for improving comorbid sleep disturbance, with gradual upward titration based on analgesic response and tolerability

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For example, atypical metabolite concentrations in SM1, thalamus, mPFC, and SMA may relate to sensory and motor symptoms common to autism(Ford & Crewther, 2016

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