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In HCC, FOXO3a acts as a significant tumor suppressor, exerting a critical role in inhibiting the growth and advancement of tumors [105]

L-theanine ameliorated 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced erythema, increased vascular permeability, epidermal and dermal hyperplasia, and neutrophil infiltration via decreasing platelet endothelial cell adhesion molecule (PECAM)-1 expression and the production of pro-inflammatory cytokines including IL-1, tumor necrosis factor (TNF)- and cyclooxygenase (COX)-2 [34]

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Since this function is similar to the one by antioxidant substance, many of it is thought to have a similar effect as SOD