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MicroRNA 146a is recognized for its interaction with intracellular adaptor proteins, including interleukin 1 receptor-associated kinase 1 and tumor necrosis factor receptor-associated factor 6, both of which participate in cytokine-dependent signal transduction and downstream nuclear factor-mediated responses

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This consideration explains why, under excess H 2 O 2 , cells with an initially higher GSH concentration display a faster GSH oxidation

Consequently, mitochondrial dysfunction facilitates a decrease in ATP production, Ca 2+ dyshomeostasis, and ROS generation
