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Even though the effect of exercise was not distinguishable among the two PCC groups, which segregated distinctly from the no-PCC group, certain inflammatory markers, notably S100A8 and CST3 showed a downward trend in paired analysis of the pre- and post-exercise group

10.1021/acschembio.5b00245 39 DobrianA

In particular, mossy fiber sprouting in hippocampal dentate granule cells lowers the seizure threshold and contributes to cognitive and emotional impairments (Hajszan and MacLusky, 2006)

E., AbdelShaheed C., Underwood M., et al., Efficacy, Safety, and Tolerability of Antidepressants for Pain in Adults: Overview of Systematic Reviews, Bmj 380 (2023): e072415