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Akiyama H, Zhao R, Nishida Y, Ostermann LB, Mak PY, Ayoub E, Piya S, Carter BZ, Andreeff M , Ishizawa J

Collectively, these recent contributions argue that future GSH-centric redox sensing and nanomedical approaches should (i) incorporate organelle targeting (especially mitochondria) to exploit subcellular redox heterogeneity, (ii) embed analyte-responsive activation into both therapeutic and imaging components, (iii) combine biochemical sensing with optical or thermal engineering for spatiotemporal control, and (iv) favor clinically translatable carriers (e.g., PLGA) for delivery

Carotenoids are insoluble in water, but are very soluble in fats or non-polar solvents, with which they often form esters