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MOTS-C enhances mitochondrial function and cellular energy production, improves insulin sensitivity and glucose metabolism, and supports metabolic flexibilityoptimizing energy utilization across all cells and tissues

Dietary intake: Vegetarians, vegans, and those who limit their daily consumption of animal products may have to consume more vitamin B12, as it is mainly present in foods of animal origin

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This is complicated because as a polar, charged tripeptide, transport of GSH is significantly inhibited by the blood-brain barrier (BBB), thus limiting effective delivery to brain-resident immune cells such as microglia which are central drivers of neuroinflammatory pathology (Valdovinos-Flores and Gonsebatt, 2012