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The following databases were searched: Ovid MEDLINE, MEDLINE In-Process and Other Non-Indexed Citations, Ovid Embase, Wiley Cochrane, EBSCO Cumulative Index to Nursing & Allied Health Literature (CINAHL), and Centre for Reviews and Dissemination/International Agency for Health Technology Assessment

(2016) Effects of acetyl-L-carnitine and methylcobalamin for diabetic peripheral neuropathy: A multicenter, randomized, double-blind, controlled trial

Malinow's concern was based on the result of our study of the Framingham Offspring cohort (38), which showed that, in subjects who were taking vitamin supplements, folic acid fortification was associated with significantly higher serum total homocysteine (tHcy) concentrations than at baseline ( Figure 2 )

There were no signs of hyperpigmentation in the oral cavity