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Finally, AC regulates macrophage polarization (favoring M2 over pro-inflammatory M1 phenotype), which can promote tissue repair and resolution of inflammation (Ren et al

Single-cell barcoding and dynamical systems approaches further support this view, showing that aged MuSCs follow the same differentiation trajectories as young cells but stall near commitment checkpoints, suggesting delayed progression rather than lineage restriction

PGPIN I, II and III groups were respectively gavaged PGPIN at 0.025mg, 0.25mg and 2.5mg/kg body weight each day before alcohol gavage, and GSH group was gavaged GSH at 2.5mg/kg body weight as positive control