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While surgical therapy remains the gold standard for chronic severe PD, there is a myriad of other less invasive treatment options, namely oral and intralesional medications

N Engl J Med 366(7):636646 Fogel BL, Perlman S (2007) Clinical features and molecular genetics of autosomal recessive cerebellar ataxias

Similarly, CUMS models show reduced mitochondrial membrane potential, impaired ATP production, decreased PINK1 and Parkin expression, alongside increased mtROS, p62, and apoptosis-associated speck-like protein containing CARD (ASC)
Cancer The link between sugary drinks and cancer risk has received far less attention
