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[DOI] [PMC free article] [PubMed] [Google Scholar] 110.Yang B.C., Castells M.C

A recent meta-analysis of 12 observational studies found that higher dietary intake of vitamin B 12 was associated with a 23% lower risk of depression compared to lower intakes, but stratifying the data revealed a significant protective association in females, not in males (99)

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2 More recent work has clarified one striking pathway: growth hormone signaling activates the MEKERK cascade, which phosphorylates and inactivates the transcription factor PPAR, downregulating fat-specific protein 27 (FSP27, also called CIDEC)